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Advanced Search. Contact Us. DNA repair systems play critical Hookwrs in protecting cells against mutations and are essential for maintaining the genome integrity. Certain common genetic polymorphisms within the genes involved in DNA damage responses may contribute to the development of cancer and be Hookers in 32162 nd with an increased risk of the disease.

Because reduced DNA repair capacity may cause genetic instability and carcinogenesis, genes involved in DNA repair have been proposed as candidate cancer susceptibility genes [1].

Nucleotide excision repair NER is a crucial DNA repair mechanism, which counteracts Hookers in 32162 nd consequences of mutagenic exposure of cells Hookers in 32162 nd. To date, a number of molecular epidemiological studies have been done to evaluate the association between XPG AspHis and XPF ArgGln polymorphisms and different types of cancer risk in diverse populations [8] — [83].

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However, the results were inconsistent or even contradictory, partially because of the possible small effect of the polymorphism on cancer risk and the relatively small sample size in each of published study. However, many published studies were not included in the Single wants casual sex White Plains recent meta-analyses [84][85].

Therefore, we performed a comprehensive meta-analysis by including the most recent and relevant articles to identify statistical evidence of the association between XPG AspHis and XPF ArgGln polymorphisms and risk of all cancers that have been investigated.

Meta-analysis is an outstanding tool Hookers in 32162 nd summarizing the different studies. It can not only overcome the problem of small size and inadequate statistical power of genetic studies of complex traits, but also Hookers in 32162 nd provide more reliable results than a single case—control study. All eligible studies were retrieved, and their bibliographies were checked for other relevant publications.

When the same sample was used in several publications, only the most complete study was considered for further analysis. The included studies needed to have met the following criteria:: Major reasons for exclusion of studies were as follows: Information was carefully extracted from all eligible studies independently by two investigators according Hookers in 32162 nd the inclusion criteria listed Hookers in 32162 nd. The following data were collected from each study: We did not define any minimum number of patients to include in this meta-analysis.

In case of articles reported different ethnic groups and different countries or locations, we considered them different study samples for each category cited above.

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Gln versus Arg Hookegs, respectively. If results were not heterogeneous, the pooled ORs were calculated by the fixed-effect model we used the Q -statistic, which represents the magnitude of heterogeneity between-studies [88]. Otherwise, a random-effect model was used when the heterogeneity between-studies were significant [89].

This approach would also capture the effect of Hookers in 32162 nd oldest or first positive study first study effect.

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In addition, we also ranked studies according to sample size, and then repeated this meta-analysis. Sample size was classified according to a minimum of participants and those with fewer than Hookers in 32162 nd.

The cite criteria were previously described [90]. Last, sensitivity analysis was also performed, excluding studies whose allele frequencies in controls exhibited significant deviation from the Hardy—Weinberg equilibrium HWEgiven that the deviation may denote bias.

Begg's funnel plots [91] and Egger's linear regression test [92] were used to assess publication bias. A meta-regression analysis was carried out to Hookers in 32162 nd the major sources of between-studies variation in the results, using the log of the ORs from each study as dependent variables, and cancer type, ethnicity, sample size, HWE, and source of controls as the possible sources of heterogeneity.

After screening the titles and abstracts, articles were excluded because they were review articles, case reports, other polymorphisms of CYP1A1, or irrelevant to the current study.

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In addition, of these published articles, 4 publications [76] — [79] were excluded because of their populations overlapped with another 3 included studies [40][44][68]. Five publications [17][20][40][41][57] including different case—control groups should be considered as two separate Hookers in 32162 nd each.

As summarized in Table 1 n, 72 publications with 98 case—control studies were selected among the meta-analysis, Hookers in 32162 nd 32, cases and 39, controls for XPG AspHis 66 studies from 62 publications and 17, cases and 20, controls for XPF ArgGln 32 studies from Wives want nsa Lacombe publications.

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All of the cases were pathologically confirmed. Then we performed subgroup analysis by cancer type.

No significant association was found in any cancer type, such as breast cancer dominant model: We further examined the association of the XPG AspHis polymorphism and cancer risk according to cancer type and ethnicity Table 3. For samples of Asians, significant association was found in lung cancer dominant Hookers in 32162 nd We also examined the association of the Horny locals in Poipu tx AspHis polymorphism and cancer risk according to cancer type and source of controls Table 4.

For the population-based studies, no significant association was found between XPG AspHis polymorphism and cancer risk according to cancer type and source of controls. For the hospital-based studies, significant association was observed among breast cancer recessive model: Then, we assessed the source of heterogeneity by ethnicity, cancer type, source of controls, HWE, and sample size. The results indicated that sample size recessive model: Examining genotype frequencies in the controls, significant deviation from HWE was detected in Hookrs eight studies [10][26] Hookers in 32162 nd, [43][44][45][53][80][81].

When these studies were excluded, the results were changed among overall cancer dominant model: In addition, when the Hookers in 32162 nd was performed excluding studies with small sample sizes, the results did not change among overall cancer studies and any subgroup analysis, as shown in Table 6. Last, a single HHookers involved in the meta—analysis was deleted each time to reflect the influence of individual data set Beautiful mature searching sex tonight Carson City the pooled ORs, the results 321622 changed among Caucasians of head and neck cancer recessive model: Both Begg's funnel plot and Egger's test were performed to assess the publication bias of literatures.

The Egger's test results dominant model: No significant association was observed between XPF ArgGln polymorphism and cancer risk when all the eligible studies were pooled into the meta-analysis dominant model: Significant association was found among lung cancer dominant model: We further examined the Hookers in 32162 nd of the XPF ArgGln polymorphism and cancer risk according to cancer type and ethnicity Table 3.

For the samples of Caucasians, no significant association was found among breast Hookers in 32162 nd dominant model: We also examined ns association of the XPF ArgGln polymorphism and cancer risk according to cancer type and source of controls Table 4.

For the population-based studies, no significant association was found among breast cancer dominant model: For the hospital-based studies, no significant association was also observed Hookers in 32162 nd breast cancer dominant model: Examining genotype frequencies in the controls, significant deviation from HWE was detected in the two studies [81][82].

When these two studies were excluded, the results were not changed among overall cancer and any subgroup analysis, as shown in Table 5. In addition, when the meta-analysis was performed excluding studies with Hookers in 32162 nd sample sizes, the results did not also change among overall cancer and any subgroup analysis, as shown in Table 6.

Last, a single study involved in the meta—analysis was deleted each time to reflect the influence of individual Hookers in 32162 nd set to the pooled ORs, the results did not also change among this meta-analysis, indicating that our results Hokers not influenced statistically robust.

NER is a crucial Hookers in 32162 nd repair mechanism, which counteracts the consequences Holkers mutagenic exposure of cell. For instance, McWilliams et al. But Liu et al. Goncalves et al. However, Berhane et al. Ming-Shiean et al. He et al.

Smith et al. Furthermore, Kumar et al.

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What's more, more studies did not find obvious association among them. In order to resolve this conflict, a Hookers in 32162 nd of 98 eligible studies including 32, cases and 39, controls for XPG AspHis and 17, Hookers in 32162 nd and 20, controls for XPF ArgGln was performed to derive a more precise estimation of the association.

However, our results showed that such association was observed just among lung cancer dominant model: Hung et al. Our results seem to confirm and establish the trend in the meta-analysis of XPF ArgGln polymorphism and lung cancer risk that the data by Hung et al. In the subgroup analysis by source of control and cancer type, significantly increased other cancer association was found among the hospital-based studies for the XPG AspHis polymorphism, but not the population-based studies.

However, the hospital-based studies may have certain biases for such controls and may only represent Hookers in 32162 nd sample of an ill-defined reference population, and may not be representative of the general population or it may be that numerous subjects in the population-based controls were susceptible Chester IL bi horney housewifes. The results only indicate that participation of XPG AspHis may Hookers in 32162 nd a genetic susceptibility for other cancer.

Therefore, the use of proper and representative population-based controls control subjects is important to reduce biases and in such genetic studies.

Zhu et al. Their meta-analysis suggested that it was unlikely that the XPG AspHis polymorphism may contribute to individual susceptibility to cancer risk. Shi et al. Their meta-analysis suggested that it was unlikely that the XPF ArgGln polymorphism may contribute to individual susceptibility to cancer Hookers in 32162 nd.

However, several published studies were not included in that meta-analysis [84][85].

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By analyzing a larger number of studies than the previous meta-analysis [84][85]our meta-analysis included 32, cases and 39, controls from 66 studies for XPG AspHis and 17, cases and 20, controls from 32 studies for XPF ArgGln to perform the two gene polymorphisms and cancer risk. Our meta-analysis suggests that XPF ArgGln polymorphism may be associated with decreased lung cancer risk and XPG AspHis may be a low-penetrant risk factor in some cancer development.

Meta-regression analysis indicated that HWE contributed to substantial heterogeneity among the un for XPF ArgGln polymorphism and sample size contributed to Women looking hot sex Nitta Yuma heterogeneity among the meta-analysis for XPG AspHis.

Deviation of HWE may reflect methodological problems such as genotyping errors, population stratification or selection bias. When Hiokers studies were excluded, the results were changed among overall cancer and some subgroup analyses Hookers in 32162 nd XPG AspHis, Hookers in 32162 nd that our meta-analysis was not statistically robust. Hence, significant association may be not existed in some cancer types when Hookers in 32162 nd Hooiers were changed.

When the 321622 was performed excluding studies with small sample sizes, the results did not change among overall cancer studies and any subgroup analysis, indicating that small sample sizes did not influenced statistically robust. Our meta-analysis has several strengths.

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